Epidermolysis bulosa

Dermal-Epidermal Junction (DEJ). The DEJ is a specialized attachment area forming an extensive interface between the epidermis and the dermis. The major function of the DEJ is to keep the epidermis and dermis firmly attached. Sulfur mustard. Bullous Pemphigoid, and forms of Epidermolysis Bulosa fonn vesicles (blisters) at this junction. 

The disease epidermolysis bulosa involves severe skin ulceration and even loss of the ends of the ears, nose, and fingers. It is the result of a primary defect in the stability of lysosomal membranes. 

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