Ephrins activation

Fig. 6. Activation of the bi-directional Eph/ephrin signaling pathway. Upon binding, the molecules form a 2 2 circular heterotetramer causing the phosphorylation of their cytoplasmic domains. The domains symbols are the same as in Fig. 1. The phosphate groups are depicted as small circles.

Himanen, J. P. et al. (2004). Repelling Class Discrimination Ephrin-A5 Binds to and Activates EphB2 Receptor Signaling. Nat. Neurosc. 7, 501-509. 

Knock-down of kalirin-7 levels reduces basal spine density and the frequency of miniature excitatory postsynaptic currents (mEPSCs) (Xie et al., 2007). Also, kalirin has been linked to the EphB receptor. Activation of the EphB receptor by ephrin-B has been shown to translocate kalirin-7 to synapses where it locally... 

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