Enzymes chemo-enzymatic access

Over the last decade in vitro enzymatic catalysis has established itself as an indispensable tool in the synthesis of small molecules both at the academic and industrial level. Examples can be found in the production of pharmaceutical intermediates where biotechnology is generating significant turnover and reducing environmental impact [1]. The success of enzyme catalysis in these reactions is based on the selectivity and efficiency of enzymes by promoting reactions that are not easily accessible by conventional techniques. Examples are the replacement of tedious protection/deportation chemistry (chemo- and regioselectivity) and asymmetric synthesis of chiral compounds (enantioselectivity). 

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