Enzyme proteolytic, cell protection against

Why this elaborate mechanism for getting active digestive enzymes into the gastrointestinal tract Synthesis of the enzymes as inactive precursors protects the exocrine cells from destructive proteolytic attack. The pancreas further protects itself against self-digestion by making a specific inhibitor, a protein called pancreatic trypsin inhibitor (p. 231), that effectively prevents... 

Interleukin-8 and C5a are released in the ischemic myocardium and may have a crucial role in neutrophil recruitment.29 Neutrophils are cells rich in oxidant species and proteolytic enzymes and can cause cell injury. In fact, annexin 1, a potent inhibitor of neutrophil extravasation in vivo was shown to protect the heart against ischemia and reperfusion injury.30 However, the importance of neutrophil in causing myocardial damage in the context of ischemia and reperfusion is now questioned. Experimental evidence shows that the time course of neutrophil accumulation in postischemic myocardium seems to be different from the time course of injury, myocardial injury is observed in neutrophil free conditions and anti-inflammatory interventions do not consistently limit infarct size, reviewed by Baxter.31... 

Properties and functions. Due to their high viscosities, the G. serve as lubricants and protective agents, e.g. against proteolytic enzymes, bacteria and viruses They play a role in cellular adhesion and contact inhibition of cell growth in tissue culture. They are also responsible for cellular recognition of foreign tissue. 

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