Enzyme-mediated glycopeptide synthesis

The enzymatic synthesis of glycopeptides does not require protection of the functional groups of the amino acid side chains and sugar hydroxyls, because of the high stereoselectivity and regioselectivity of proteases. However, the substrate selectivity of these enzymes may limit a wider range of applications. 

Moroder, A, Hallett, A. Wiinsch, O. Keller and G. Wersin, 1976, Hoppe-Seylers Zeitschrift Physiol. Chem., 357, 1651 (b) D.S. Tarbell, Y. Yamamoto and B.M. Pope, 1972, 

Higashi, K. Nakayama, T. Soga, E. Shioya, K. Uoto and T. Kusama, 1990, Chem. Pharm. Bull, 38, 3280. 

Albericio, N. Kneib-Cordonier, S. Biavcalana, L. Gera, R.I. Masada, D. Hudson and 

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