Enzymatic detoxification, conjugation

The passage from one step to the next along the continuum will often depend on a person s characteristics. A biomarker that allows the assessment of a person s susceptibility to alter the progression along the continuum is called a biomarker of susceptibility. Examples are enzymatic genotypes and phenotypes, such as those seen with glutathione-S-transferase M, a phase II conjugation enzyme that often contributes to the detoxification of some electrophilic compounds (Perbellini et al. 2002). 

Pflugmacher, S., Wiegand, C., Oberemm, A., Beattie, K.A., Krause, E., Codd, G.A. and Steinberg, C.E.W. Identification of the enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR the first step of detoxification, Biochem. Biophys. Acta., 1425, 527, 1998. 

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