Enzymatic degradation polyelectrolyte complexes

We thank very much Dr Tomas Etrych who contributed to the study of polyelectrolyte complexes by DLS and selective enzymatic degradation. 

With the anionic genetic materials, these vectors form polyelectrolyte complexes, sometimes endowed with modest positive charge, that greatly reduce the enzymatic degradation of the genetic materials and are often readily taken up by cells. The biochemistry of the cellular uptake of such complexes is probably mediated by the electrostatic interaction of the nanocomplex with the anionic cellular membrane (Mounkes et al., 1998). Once inside the cell the complex unwinds, setting the genetic material free to execute its function. 

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