Enzymatic degradation drugs susceptible

Peptides are not the only potential drug candidates. In most cases, other kinds of small organic molecules are preferred, because of their reduced susceptibility to enzymatic degradation. The split-mix method is fully applicable in the synthesis of organic libraries. Both sequential type and cyclic libraries can easily be prepared if the reaction conditions for solid phase are well developed. It has to be emphasized, however, that the advantages of the split-mix method can be fully exploited only in the case of multi-step synthetic procedures. For realization of the one-pot procedures suggested by Ugi [10], for example, the parallel procedures are better-suited. 

Delivery of large-molecular-weight, biotechnology-produced drugs info the body is difficult because of the poor absorption of these compounds, the acid lability of peptide bonds, and the rapid enzymatic degradation of these drugs in the body. In addition, protein pharmaceuticals are susceptible to physical instability, complex feedback control mechanisms, and peculiar dose-response relationships. 

This system is advantageous for drugs that are highly susceptible to degradation by enzymatic processes, since it offers a protective mechanism by temporarily altering the substrate. This approach to... 

---