Enzymatic catalysis steady-state concept

Figure 6.2. Illustration of the steady-state concept in enzymatic catalysis From equality of the rates k] [E] [S] = k[ES] + k 2 [ES]...

Fig. 6.2 Illustration of the steady-state concept in enzymatic catalysis. (From http //chemwiki.ucdavis. edu/ api/deki/files/54230/512px-Michaelis Menten S P E ES.svg.png revision—l).

In the following derivation we will apply the concept of steady state approximation, which was introduced to enzymatic catalysis by Briggs and Haldane (1925), who had proposed that the rate of formation of ES = ki [E][S] balances the rate of breakdown of the complex ES = (k i + k2)[ES], or in other words (Figure 6.2) d(ES)/dt = 0... 

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