Environmentally responsive biomaterials applications

PKA and AP, respectively (Wang et al 2010 Zelzer, McNamara, et al 2012), as well as the triggered availability of a peptide sequence on the surface (Todd et al 2009). As peptides are natural substrates for enzymes, enzymatic response of a peptide surface appears to be an ideal way to interface a biomaterial surface with a living system. Enzymatic stimulation of peptide surfaces has the advantage that the environmental conditions required (physiological conditions) are ideal for both the peptide and the stimulus. For applications in living systems, emphasis must be placed on a well-designed peptide surface to prevent unwanted interaction with other enzymes. 

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