Environmental Fate of Microtubulin Assembly Inhibitors Pyridines

Environmental Fate of Microtubulin Assembly Inhibitors (Pyridines) [16] 

The photolytic half-life in water was 17.6 days, indicating a moderate rate of degradation and a potential for degradation in surface water. The two monoadds and the diadd were the primary metabolites observed. The potential movement in water would be limited due to the low water solubility of dithiopyr and its strong adsorption to soil partides and plants. 

In plants, oxygenases metabolize the dihydrothiazole ring to the sulfoxide, sul-fone, hydroxyl derivative and thiazole. Thiazopyr is also deesterified to its carboxylic acid. 

Organism Administered Measure Dithiopyr value Thiazopyr value  

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