Environmental factors adverse drug reactions

Fig. 1 The multigenic and multifactorial nature of idiosyncratic adverse drug reactions. The occurrence of an idiosyncratic reactions is dependent on the interaction between multiple genes and environmental factors...

Figure 2 The prolonged mechanical ventilation care process cycle. Patient health status determines the potential for liberation of chronic ventilation dependency. However, environmental influence (reduction of infection, adverse drug reactions, etc.), available resource either professional or economic, and the cultural and ethical beliefs are also important interdependent factors for success.

In a Lebanese study in 17 patients, mainly with thalassemia major, there were no serious adverse reactions to deferiprone 50-75 mg/kg/day (11). Joint pain, stiffness, or sweUing occurred in six patients the symptoms were severe in two and mild in four patients. Seven patients had nausea, especiaUy in the first month of treatment, and two had a reduced appetite. Headache developed in four patients. Mouth ulcers, sore throat, bitter taste, and fatigue occurred in single cases. In one patient there was a weakly positive ANE after 6 months. There were no cases of granulocytopenia and in none of the patients did adverse effects require drug withdrawal. The authors suggested that environmental or hereditary factors might have influenced the results. 

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