Envirocat EPZG

Acylation reactions. Methoxyacetophenones and methoxypropiophenones can be obtained from acylation of methyl phenyl ether with the corresponding acid anhydrides and acid chlorides at 70 "C over Envirocat EPZG in 35 to 72 % yield. Other important reactions catalysed by this catalyst include acylation of PhNHCOCHi to acetamidoacetophenones and 1,3,5-trirnethylbenzene to 1,3,5- trimethylacetophenone. 

Varma, R.S. and Dahiya, R., Microwave-assisted facile synthesis of imines and enamines using envirocat EPZG as a catalyst, Synlett, 1997, 1245. 

Keywords benzaldehyde, aniline, ketone, secondary amine, Envirocat EPZG, microwave irradiation, imine, enamine... 

To a clean reaction vessel add benzaldehyde (0.53 g, 5.0 mmol), aniline (0.61 g, 10 mmol), and Envirocat EPZG (0.10 g), which is dried by distillation with tolune prior to the reaction. 

Extract the product into dichloromethane (10 ml), remove Envirocat EPZG by fitrtation and wash it with dichloromethane (3 x 10 ml). 

Zeolite Y, Envirocat EPZG," CAN, silica gel, Montmorillonite clay K 10 or KSF, InBrs/polyethylene glycol, " Fe2(S04)3-xH20, " Well-Dawson heteropolyacid,CBr4, SnCL 21120,NaHS04, polyethylene glycol. ... 

Knoevenagel condensation under focused MWI for 1-7 min of 2-hydroxy or 2-methoxy-substituted benzaldehydes or acetophenones 99 and Meldrum s acid (100) using a solid catalyst combination of natural kaolinitic clay or Envirocats (EPZG, EPZIO) gave 3-carboxycoumarins 101 in 55-97% yields (Scheme 20) (99MI4). 

Figure 16.14 The preparation of 2-chloro-5-nitrobenzophenone using Envirocat EPZG.

Envirocat EPZG Acylations Benzoylations Truly catalytic Does not complex with products... 

The reaction involving a mixture of benzyl alcohol, nitrile and Envirocat EPZG catalyst was stirred under microwave irradiation in a microwave reactor for a given time. After cooling to room temperature, this is further treated with CH2CI2. The catalyst can be removed by filtration and the residue can be recrystallized from ethanol-water (Veverkova and Toma, 2005). 

---