Entropic paradox

As a consequence of the temperature dependence of A/ftf and ASjj, AGn(D shows a bell-shaped curve an example is given in Fig. 2. This has two important implications (1) AG CT), which measures the stability of the protein, passes through a maximum at a temperature Fmax, usually in the 0-50°C range, at which the native conformation is stabilized only by the enthalpy difference between the two states. As already stressed in the introduction, AGN(Fmax) is rather small, albeit it results from comparatively large enthalpic and entropic effects typical values are of the order of 50 kJ per mole of protein. (2) On both sides of Fmax, stability decreases and there are two temperatures at which AG becomes zero, i.e., denaturation occurs the upper one corresponds to the temperature of the usual heat denaturation process, the lower one to the somewhat paradoxical process of cold denaturation the paradox lies in that cold denaturation is an exother-... 

Spontaneous film reorganization seems to be quite a common phenomenon. It has been observed that even an SPAAP bilayer reorganizes such that patches of 0, 2, 4, and 6 layers are all readily observable (Figures 8 and 9). Schwartz etal, who have observed similar phenomena with odd numbers of layers," " ruled out the entropic effects that seem to drive thermal crystal roughening as a possible mechanism but pointed out the paradox of unfavorable... 

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