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Enthalpy as a Key Decision Tool in Medicinal Chemistry

It is also noteworthy that the entropic penalty for trapping an interstitial water molecule is significantly overcompensated by the formation of hydrogen bonds with the interstitial water and the protein, in particular main chain hydrogen bond donor and acceptor groups. [Pg.372]

Importance of Enthalpk Interactions Drivers of Selectivity and Specificity  [Pg.373]


See other pages where Enthalpy as a Key Decision Tool in Medicinal Chemistry is mentioned: [Pg.371]    [Pg.371]   


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