Enteric coating cellulose acetate trimellitate

The salt form of the polymer may also play a role in determining the performance of the formulation. Kane et al. [32] found that cellulose acetate phthalate was more effective than cellulose acetate trimellitate in controlling the dissolution of sulfothiazole-sodium tablets with cellulose acetate. The enteric properties of hydroxypropylmethylcellulose phthalate (HPMCP) were found to depend on the solubility of the drug that was coated. 

In 1940, Eastman Kodak Company published a U.S. patent that provided one of the earliest de.scriptions of enteric coating of medicaments. The patent claimed the use of a cellulose derivative containing free carboxyl groups as an enteric film forming polymer. Specifically, the claimed enteric polymer was cellulose acetate phthalate (CAP) (34). Numerous enteric cellulose derivatives have been developed since this early account and these polymers remain as some of the most widely used for enteric coating applications. In addition to CAP these derivatives include cellulose acetate trimellitate (CAT), cellulose acetate succinate (CAS), hydroxypropyl methylcellulose phthalate (HPMCP), and hydroxypropyl methylcellulose acetate succinate (HPMCAS). The molecular structure of these polymers is depicted in Figure 1 with their respective substituent groups listed in the caption. 

C-A-T Enteric Coating Polymer. [Eastman] Cellulose acetate trimellitate. 

Catemol DLO. See Dimethyl lauramine oleate Catemol 118 ES. See Isostearamidopropyl ethyidimonium ethosulfate Catemol L 18 ES. See Linoleamidopropyl ethyidimonium ethosulfate Catemol S-180, Catemol S180-S. See Stearamidopropyl dimethylamine stearate C-A-T Enteric Coating Poiymer. See Cellulose acetate trimellitate... 

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