Ent-Isokaurene

Hedden, P., Phinney, B.O. "Comparison of ent-kaurene and ent-isokaurene synthesis in cell-free systems from etiolated shoots of normal and dwarf-5 maize seedlings."... 

There are a number of branches between MVA and ent-kaurene that lead to biologically important terpenes other than the gibberellins for example, in plants, a branch at IPP leads to the side chain of cytokinins a branch at FPP leads to squalene and the sterols, also abscisic acid branches at GGPP lead to phytoene, fatty acid esters, chlorophyll esters and non-cyclic diterpenes and branches at CPF lead to (-)-trachylobane, (-f)-beyerene, ( f)-sandaracopiinaradiene (21) and ent-isokaurene (22). (For a review of the pathway to ent-kaurene see reference 23). 

Figure 9. Proposed scheme for the conversion of CPP to ent-kaurene and ent-Isokaurene (22). In the dwarf-5 nnitant the pathway to ent-1sokaurene is favored, ent-Isokaurene is biologically inactive ( ).

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