Enoximone Theophylline

THEOPHYLLINE PHOSPHODIESTERASE INHIBITORS-ENOXIMONE Theophylline may i efficacy of enoximone Possibly competitive inhibition of phosphodiesterases Be aware watch for poor response to enoximone... 

ENOXIMONE BRONCHODILATORS -THEOPHYLLINE Theophylline may si efficacy of enoximone... 

An experimental study into the mechanism of action of enoximone in 14 patients with ischaemic or idiopathic dilative cardiomyopathy found that pretreatment with intravenous aminophylline 7 mg/kg given over 15 minutes reduced the beneficial haemodynamic eflects of intravenous enoximone 1 mg/kg given over 15 minutes. This appears to occur because each drug competes for inhibition of cAMP specific phosphodiesterases in cardiac and vascular smooth muscle. Milrinone, another phosphodiesterase inhibitor similar to enoximone, would be expected to interact in the same way. However, there are, at present, no published reports of a possible interaction with milrinone, and no case reports of a problem occurring with the concurrent use of either drug with theophylline. The clinical importance of this study therefore awaits evaluation. 

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