Ranitidine Enoxacin

Misiak PM, Eldon MA, Toothaker RD, Sedman AJ. Effects of oral cimetidine or ranitidine on the pharmacokinetics of intravenous enoxacin. J Clin Pharmacol 1993 33(l) 53-6. 

Grasela TH, Schentag JJ, Sedman AJ, Wilton JH, Thomas DJ, Schultz RW, Lebsack ME, Kinkel AW. Inhibition of enoxacin absorption by antacids or ranitidine. Antimicrob Agents Chemother (19S9) 33, 615-17. 

Cimetidine can increase the serum levels of some quinolones (intravenous enoxacin or fleroxacin and oral clinafloxacin or pe-floxacin). Famotidine can reduce the serum levels of norfloxacin, and ranitidine can reduce the absorption of enoxacin. None of these interactions appear to be clinically important. 

In one study ranitidine 150 mg twice daily did not affect the pharmacokinetics of a single 400-mg intravenous dose of enoxacin. However, in another, ranitidine 50 mg given intravenously 2 hours before a single 400-mg oral dose of enoxacin reduced the absorption by 26 to 40%, which seemed to be related to changes in gastric pH caused by the ranitidine. ... 

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See also in sourсe #XX -- [ ]

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