Enolates a-alkylation

Reaction of the proline derivative 8 with pivaldehyde (1) in CH2C12 catalyzed by TFA results in a single product (9). Treatment of 9 with MeLi and then with LDA furnishes the enolate a. Alkylation or reaction with aldehydes or acetone followed by acid hydrolysis furnishes enantiomerically pure 2-substituted 4-hy-droxyprolines (10), with retention of configuration.3... 

Keywords Allylic alkylation Asymmetric catalysis Decarboxylation Enolate a-alkylation Palladium catalysis PHOX ligands Quaternary stereocenters... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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