Enhancement of Binding and Catalysis by Guest Design

By guest design is meant preparation of that framework of the guest molecule most appropriate to mimic a native enzyme reaction for a given reaction and a given host. In this section, we will discuss the scope of guest design by the use of unmodified cyclodextrins. 

Binding and Rate Constants for Deacylation of Various p-Nilrophenol Eslers  

In Table XXII are shown reactions catalyzed by cyclodextrins. It is shown that some condensation reactions are also remarkably catalyzed by the use 

Another successful example of such guest design is the Diels-Alder reaction markedly accelerated by the cyclodextrin inclusion. As shown in Table XXIV, /J-cyclodextrin accelerates the addition of a small dienophile to cyclopentadiene, but inhibits that of N-ethylmaleimide to anthracene-9-carbinol (117). Thus, the guest design is a really helpful concept for the remarkable catalysis. However, there seems to be some limitation in the choice of reactions, if cyclodextrins have no special functional group for the 

Reaction scheme of allylation and oxidation of hydroqui none derivatives catalyzed by cyclodextrin. 

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