Energy landscape temperature variations

It must be outlined that the classification of energy varieties made above is not a simple matter of presentation, for having a satisfactory view on the energy landscape. It has a fundamental and deep meaning that can be described as the key concept allowing the behavior of physical and chemical systems to be understood at a first level A system may contain several energy varieties in different proportions. This variety composition may depend on various parameters (temperature, pressure, etc.) and may change with their variations. 

It is important to recognize that the role of conformational entropy of polymer chains in various biological processes cannot be treated as only a minor factor. Since the temperature T is essentially fixed for a given physiological system and because only rather minor variations are permitted in E for a fixed T, the only way the free energy landscape can be dramatically modified must... 

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