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Enediynes cobalt-catalyzed cyclizations

Estrones. An A —> BCD approach to estrones involves a cobalt catalyzed intramolecular 2 + 2 -y 2] cycloaddition of the enediyne 1 to form the B, C. and D rings in one step. The high stereoselectivity suggests that the cyclization involves a Dicls-Alder-type reaction of the vinyl group with a cobaltacyclopentadiene formed by coupling of the two alkyne units. The homoannular diene obtained on demetalation is isomcrized easily to the diene 3. [Pg.161]

See other pages where Enediynes cobalt-catalyzed cyclizations is mentioned: [Pg.255] [Pg.17] [Pg.371]

See also in sourсe #XX -- [ Pg.3 , Pg.255 ]

See also in sourсe #XX -- [ Pg.255 ]

See also in sourсe #XX -- [ Pg.3 , Pg.255 ]

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Catalyzed Cyclizations

Cobalt-catalyzed Cyclizations

Enediyne