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Endothelium-derived relaxing factor nitrosothiols

E. Thiols, Nitric Oxide, Nitrosothiols, and Endothelium-Derived Relaxing Factor... [Pg.31]

Part of the controversy over the identity of the endothelium-derived relaxant factor relates to S-nitrosothiols (such as S-nitrosocysteine), which decompose in solution to give NO that is converted into nitrite in the presence of oxygen. ... [Pg.63]

Proposed mechanism by which nitroglycerin and the organic nitrates produce relaxation in vascular smooth muscle. Nitrates induce endothelial cells to release NO or a nitrosothiol (endothelium-derived releasing factor, or EDRF). EDRF activates the enzyme guanylate cyclase, which causes the generation of cyclic guanosine monophosphate (GMP), producing a decrease in cytosolic free calcium. The end result is vascular smooth muscle relaxation. SH, sulfhydryl. [Pg.197]

See other pages where Endothelium-derived relaxing factor nitrosothiols is mentioned: [Pg.329]    [Pg.673]    [Pg.9]    [Pg.205]    [Pg.94]    [Pg.266]    [Pg.244]    [Pg.139]   
See also in sourсe #XX -- [ Pg.31 ]



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