Enantioselective Transformations via Deprotonation

As discussed in Hodgson et al, in this volume, transformations of achiral epoxides based on enantioselective a-deprotonation have been extensively studied by Hodgson and coworkers since 1996 [49, 50] ligands used were (-)-sparteine 2 [49], (-)-a-isosparteine 28 and (usually less effectively) bisoxazolines (e.g., 30), with the bisoxazoHne study [51] being the first report of such Hg-ands in an enantioselective deprotonation. 

Beak and coworkers carried out the seminal (and much of the subsequent) studies on the use of organolithiums in enantioselective synthesis via Uthiocarban- 

1 Excepted with permission from J. Am. Chem. Soc. 2002, 124, 1889-1896. Copyright 2002 American Chemical Society. 

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