Enantioselective synthesis of -y-rhodomycinone

In the enantioselective synthesis of anthracyclinone AB building blocks Japanese workers continue to successfully exploit their methodology based on the addition of Grignard reagents to the a-carbonyl group of the ketals obtained from tetralone and (2S,3S)-l,4-dimethoxybutane-2,3-diol (60) [76]. This highly diastereoselective reaction was apphed in the synthesis of (-)-7-deoxydaunomycinone [77,78]. Later it was extended to the synthesis of AB segment 58, an intermediate in the first enantioselective synthesis of (-)-y-rhodomycinone (65) [71,79]. 

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See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

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