Enantioselective synthesis, of prostaglandin

Cu(OTf)2 (2mol%) is required (Equation (110)).183 The nature of the copper salt strongly influences the enantio-selectivity, and copper carboxylates proved to be especially efficient (Equation (lll)).184b It has been applied for an enantioselective synthesis of prostaglandin E methyl ester (Equation (112)),185 and can be used for the performance of a highly regiodivergent and catalytic parallel kinetic resolution.186... 

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