Enantioselective nickel-catalysed conjugate addition reactions

Enantioselective Nickel(ii)-Catalysed Conjugate Addition Reactions... 

The second chapter of the book covered the advances in enantioselective nickel(ii)-catalysed conjugate additions. An important breakthrough in the history of the Michael reaction was the achievement of the Michael addition of p-dicarbonyl compounds to a broad variety of electrophiles catalysed by nickel acetylacetonate, described by Nelson in 1979-1980. Since this pioneering contribution, nickel has become one of the preferred metals in catalytic Michael reactions. Later, in 1988, Soai developed the first asymmetric conjugate additions performed under chiral nickel(ii) catalysis. Ever since. 

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