Enantioselective Hydrogenation of Alkenes with Ferrocene-Based Ligands

Hans-Ulrich Blaser, Matthias Lotz, and Felix Spindler 

This chapter is organized according to the position of the phosphine groups P, as depicted in Fig. 25.2. It is important to realize that many of the ligands described here have both planar (Cp ring with two different substituents) as well 

Copyright 2007 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-31161-3 

P bound to cp ring and side chain P bound to side chains 

When assessing catalytic results reported for new ligands, one must bear in mind that their quality and relevance differ widely. For most new ligands only experiments with selected model test substrates carried out under standard conditions are available, and very few have already been applied to industrially relevant problems. The test substrates for alkenes used most frequently are Aceta-mido Cinnamic Acid (ACA) or its methyl ester (MAC), Methyl Acetamido Acrylate (MAA), ITaconic Acid or DiMethyl ITaconate (ITA, DMIT) and selected aryl enamides (Fig. 25.3). 

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Enantioselective Hydrogenation of Alkenes with Ferrocene-Based Ligands... 

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