Enantioselective aza Darzens reaction

At the same time, Antilla et al. developed a vaulted biphenanthrol (VAPOL)-based magnesium phosphate 20b mediated asymmetric aza-Darzens reaction for the synthesis of chiral aziridine derivatives. The catalyst was prepared in an identical procedure to the previously described process with VAPOL-derived phosphate and magnesium fert-butoxide, and applied in the enantioselective aza-Darzens reaction of N-benzoyl imines 23 and ot-chloro-1,3-diketone 24. The process formed a series of substituted aziridines 25 bearing various substituents at the aromatic ring, with good... 

Bianthryl derivatives. The utility of a chiral magnesium phosphate salt (386) in the synthesis of aziridines (385) via the enantioselective aza-Darzens reaction of 3-chloro-pentane-2,4-dione (384) and imines (383), has been investigated by Antilla et al. (Scheme 101). ... 

---