Enantiomer-resolving machine

The chiral resolving ability of hosts 7 ,7 3.106 and its S, S-enantiomer were investigated further by the construction of an enantiomer-resolving machine, pictured in Figure 3.73. The basis of the device is a W-shaped tube with a chloroform solution of host in the bottom of each side of the W . The S, S-enantiomer... 

Figure 3.73 The enantiomer-resolving machine. (Reprinted with permission from [48] 1979 American Chemical Society).

The chiral recognition ability of 4.2 was examined by two-phase liquid-liquid extraction experiments of racemic mixtures of amino acids and ester guests. Cram and coworkers developed an enantiomer-resolving machine based on such chiral corand receptors and found that the /f,/f-host was selectively able to extract the D-enantiomer of amino acids. 

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