Enantioenriched tetrahydro-p-carboline

Table 6.6 Asymmetric synthesis of enantioenriched tetrahydro-p-carbolines 64 reported by You.

On the basis of the above mechanistic studies, the You group designed an Ir-catalyzed tandem dearomatization/migration protocol for asymmetric synthesis of enantioenriched tetrahydro-p-carboline derivatives 190 (Table 6.16). The migratory group in this reaction is methylene adjacent... 

A catalytic as5mmetric Pictet-Spengler reaction has been developed. This process furnishes enantioenriched tetrahydro-P-carbolines (88) from various tryptamines and both aromatic and aliphatic aldehydes if treated with chiral Bronsted acid catalyst (89) (Scheme 25). ... 

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See also in sourсe #XX -- [ ]

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