Enals, asymmetric counteranion-directed

Scheme 25. Asymmetric counteranion-directed catalysis transfer hydrogenation of enals...

Scheme 2.3 Asymmetric counteranion directed conjugate reduction of enals citral and dtroneUal...

In 2008, List s group developed an epoxidation using asymmetric counteranion-directed catalysis (ACDC) [177]. In this work, the epoxidation of 1,2-disubstituted enals (33) and (3,(3-disubstituted, a, 3-unsaturated aldehydes (115) was explored. Instead of using a chiral amine (e.g. Jprgensen-Hayashi s catalyst), an achiral amine and a chiral counteranion (a phosphoric acid derived from BINOL), were employed. 

FIGURE 32.3. TRIP-derived catalysts for the asymmetric counteranion-directed reduction of enones and enals. 

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