Enalaprilat analogues

Figure 4.1 Examples of the variation of response curves with increasing numbers of inserted methylene groups, (a) A study by Dohme et al. on the variation of antibacterial activity of 4-alkyl substituted resorcinols, (b) Inhibition of ACE by enalaprilat analogues (Thorsett). The figures in brackets are the IC50 values for that analogue...

Examples of such structures with regularly increasing ring si2es are found for guanethidine (see Chapter 14), or for enalaprilat analogues (Fig. 12.2). In the latter example, a... 

The structural relationship of pivopril to the commercially important analogues captopril (51) and enalaprilat (52) is readily apparent. 

Angiotensin-Converting Enzyme Inhibition by Central Amino Acid Analogues of Enalaprilat... 

Lisinopril, a lysine analogue of enalaprilat, hardly scavenged the superoxide or the hydroxyl radicals in vitro, using an ESR method (Noda et al. 1997). 

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