Probenecid Enalapril

ACE INHIBITORS PROBENECID t plasma concentrations of captopril and enalapril uncertain clinical significance Renal excretion of captopril and enalapril l by probenecid Monitor BP closely... 

Probenecid decreases the renal clearance of captopril, but this is probably not clinically important. Probenecid decreases the renal clearance of enalapril, and raises its serum levels. 

In 12 healthy subjects probenecid 1 g twice daily for 5 days increased the AUC of a single 20-mg oral dose of enalapril and its active metabolite, enalaprilat by about 50%. The renal clearance of enalapril decreased by 12% A moderate increase in the hypotensive effects might be expected, but there do not appear to be any reports of adverse effects. 

Noormohamed FH, McNabb WR, Lant AF. Pharmacokinetic and pharmacodynamic actions of enalapril in humans effect of probenecid pretreatment. J Pharmacol Exp Ther (1990) 253, 362-8. 

---