Nicardipine Enalapril

Calcium channel blockers, including diltiazem (Cardizem SR, Dilacor XR, Tiazac), nicardipine (Cardene), amlodipine (Norvasc), felodipine (Plendil), and enalapril maleate-felodipine ER (Lexxel). 

In a study in 12 patients with hypertension taking enalapril20 mg daily, the addition of nicardipine 30 mg three times daily for 2 weeks did not alter the pharmacokinetics of enalapril. The manufacturer of spirapril briefly noted in a review that the concurrent use of spirapril and nicardipine increased spirapril plasma levels by about 25% and those of its active metabolite, spiraprilat, by about 45%. The bioavailability of nicardipine was reduced by 30%. It was assumed that the interaction took place at the absorption site. However, the changes were not considered clinically relevant. ... 

Donnelly R, Elliott HL, Reid JL. Nicardipine combined with enalapril in patients with essential h3fpertension BrJ Clin Pharmacol (1986) 22, 283S-287S. 

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