Electrophysiological Effects of Cardiac Glycosides

The toxic effects of digitalis are frequent and may be fatal. Toxicity may result from overdosage, decreased metabolism and excretion, and hypokalemia stemming from the use of thiazide diuretics, diarrhea, and vomiting. Digitalis toxicity has several manifestations  

Digitalis toxicity should also be closely observed in elderly patients and those who have had a recent myocardial infarction, as these conditions predispose to toxic reactions. 

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