Electrophilic Trifluoromethylation with Umemotos Reagents

Electrophilic Trifluoromethylation with Umemoto s Reagents A.8.1 Trifluoromethylation of the Trimethylsilyl Dienol Ether 30 

Nucleophilic Trifluoromethylation with MejSiCFj A.9.1 Nucleophilic Trifluoromethylation of Ketone 33 

A mixture of 33 (10 mmol), Me3SiCF3 (12 mmol), and THF (25 mL) cooled to 0°C in an ice bath was treated with tetrabutylammonium fluoride (20 mg). Instantaneously a yellow color developed with initial evolution of fluorotriraethylsilane. The mixture was then brought to ambient temperature and stirred. After 1 h the 

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Scheme A.12 Electrophilic trifluoromethylation with Umemoto s reagent [18].

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