Electrophilic theory of chemical carcinogenesis

One can go further by choosing the first five instead of the first three interaction paths from the data of Table 3.45, because this number is the cardinal of the employed correlation parameters in actual residual-alert-QSARs. However, though electronegativity and chemical hardness are closely related to the total energy, see Eqs. (3.160) and (3.163), using only the first three interacting residual-alert pathways seems appropriate for the present purpose. For future studies, the extra index of electrophilieity (Parr et al., 1999) can be also explicitly incorporated to test its conceptual value in the electrophilic theory of chemical carcinogenesis (Parthasarathi et al., 2004). 

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