Electrophilic aromatic halogenation

A variety of aromatic and vinylcarboxylic acids have also been decarboxylated an adaptations of this method involving the use of AIBN as chain initiator (equations 30 and 31). Unlike the classical Hunsdiecker reaction this variant is applicable to bodi election poor and electron rich aryl acids without the risk of electrophilic aromatic halogenation. 

In organic chemistry, an electrophilic aromatic halogenation is a type of electrophilic aromatic... 

An example of an electrophilic aromatic halogenation occurs in the biosynthesis of the antifungal antibiotic pyrrolnitrin. 

Purpose. This experiment extends our understanding of the experimental conditions under which electrophilic aromatic substitution reactions are carried out (also see Experiments [27] and [29A]-[29D]). It deals with electrophilic aromatic halogenation. The directive influence of the acetamido, —NHCOCH3, group on the bromination of acetanilide is explored. 

Electrophilic aromatic halogenations occur in the biosynthesis of numerous naturally occurring molecules, particularly those produced by marine organisms. In humans, the best-known example occurs in the thyroid gland during the biosynthesis of thyroxine, a thyroid hormone involved in regulating growth and metabolism. The amino acid tyrosine is first iodinated by thyroid peroxidase, and two of the iodinated tyrosine molecules then couple. The... 

The halogen carriers or aromatic halogenation catalysts are usually all electrophilic reagents (ferric and aluminium haUdes, etc.) and their function appears to be to increase the electrophilic activity of the halogen. Thus the mechanism for the bromination of benzene in the presence of iron can be repre-sfflited by the following scheme ... 

SUBSTITUENT EFFECTS IN ELECTROPHILIC AROMATIC SUBSTITUTION HALOGENS... 

Returning to Table 12 2 notice that halogen substituents direct an incoming electrophile to the ortho and para positions but deactivate the ring toward substitution Nitration of chlorobenzene is a typical example of electrophilic aromatic substitution m a halobenzene... 

Substituent Effects in Electrophilic Aromatic Substitution Halogens... 

The two mam methods for the preparation of aryl halides halogenation of arenes by electrophilic aromatic substitution and preparation by way of aryl diazomum salts were described earlier and are reviewed m Table 23 2 A number of aryl halides occur natu rally some of which are shown m Figure 23 1... 

Halogenation (Sections 4 14 and 12 5) Replacement of a hy drogen by a halogen The most frequently encountered ex amples are the free radical halogenation of alkanes and the halogenation of arenes by electrophilic aromatic substitution... 

Many of the common electrophilic aromatic substitution reactions can be conducted on indole. CompHcations normally arise either because of excessive reactivity or the relative instabiUty of the substitution product. This is the case with halogenation. 

The reaction exhibits other characteristics typical of an electrophilic aromatic substitution. Examples of electrophiles that can effect substitution for silicon include protons and the halogens, as well as acyl, nitro, and sulfonyl groups. The feet that these reactions occur very rapidly has made them attractive for situations where substitution must be done under very mild conditions. ... 

Electrophilic aromatic substitution (Section 12.14) Halogen substituents are slightly deactivating and ortho, para-directing. Br... 

The hydroxyl group is a strongly activating, ortho- and para-directing substituent in electrophilic aromatic substitution reactions (Section 16.4). As a result, phenols are highly reactive substrates for electrophilic halogenation, nitration, sulfonation, and lTiedel-Crafts reactions. 

Unlike benzene, pyridine undergoes electrophilic aromatic substitution reactions with great difficulty. Halogenation can be carried out under drastic conditions, but nitration occurs in very low yield, and Friedel-Crafts reactions are not successful. Reactions usually give the 3-substituted product. 

Hydro-de-diazoniation seems to be an unnecessary reaction from the synthetic standpoint, as arenediazonium salts are obtained from the respective amines, reagents that are normally synthesized from the hydrocarbon. Some aromatic compounds, however, cannot be synthesized by straightforward electrophilic aromatic substitution examples of these are the 1,3,5-trichloro- and -tribromobenzenes (see below). These simple benzene derivatives are synthesized from aniline via halogenation, diazotization and hydro-de-diazoniation. Furthermore hydro-de-diazoniation is useful for the introduction of a hydrogen isotope in specific positions. 

We may ask How does Y know which side will give the more stable carbocation As in the similar case of electrophilic aromatic substitution (p. 681), we invoke the Hanunond postulate and say that the lower energy carbocation is preceded by the lower energy transition state. Markovnikov s rule also applies for halogen substituents because the halogen stabilizes the carbocation by resonance ... 

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