Electroorganic synthesis substrates

Besides advantages outlined in the introduction, the reagent electrode also has some disadvantages that limit its use. The necessary conductivity of the supporting electrolyte makes preparative scale electrolyses below — 50°C difficult because of the increased resistance of the electrolyte. Sometimes the electrode surface becomes deactivated by insulating films (passivation, see Section 2.6.2.4). However, the most serious drawback is the lack of experience with the method, which makes the potential user rather take a chemical oxidant or reductant from the shelf. Therefore, the practice of electroorganic synthesis, which involves electrodes, electrolyte, elec-troanalytical investigation of the substrate and preparative scale electrolysis will be addressed briefly in the next section. 

The templates can be covalently bound to the electrophores/substrates and serve as tethers or are more weakly attached to the reaction partners by coordinative bonds. In electroorganic synthesis, this concept was successfully applied and demonstrated in several cases. The templates work if in the course of the redox transformation either a compensation of charge is achieved or a radical center is stabilized in the neighborhood... 

First, the use of a large excess of substrate and only partially performed electroorganic conversion exploits statistics. Essentially, the electrolysis is conducted in almost neat substrate. This was realized with 2,4-dimethylphenol and is discussed in the entry Boron-Doped Diamond for Green Electro-Organic Synthesis. ... 

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