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Electron withdrawing pyrimidine nucleus

The replacement of the thiazole ring with a more electron withdrawing pyrimidine nucleus enhanaces the acidity of the NH proton by stabilizing the anion ultimately. Consequently, sulphadiazine and its metabolite are appreciably ionized at pH of blood thereby rendering them more soluble and less toxic as illustrated below ... [Pg.595]

The addition of strong electron-withdrawing substituents to the pyrimidine nucleus increases the facility and rate with which the system participates in inverse electron demand [4 + 2] cycloadditions with electron-rich... [Pg.340]


See other pages where Electron withdrawing pyrimidine nucleus is mentioned: [Pg.65]    [Pg.65]    [Pg.65]    [Pg.165]    [Pg.318]    [Pg.748]   
See also in sourсe #XX -- [ Pg.595 ]




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