Electrochemistry, metalloproteins cytochrome

The opportunity of obtaining direct electrochemistry of cytochrome c and other metalloproteins at various electrode materials such as modified gold and pyrolytic graphite has led to numerous reports of heterogeneous electron transfer rates and mechanisms between the protein and the electrode. In all the reports, Nicholson s method (37) was employed to calculate rate constants, which were typically within the range of 10" -10 cm sec with scan rates varying between 1 and 500 mV sec This method is based on a macroscopic model of the electrode surface that assumes that mass transport of redox-active species to and from the electrode occurs via linear diffusion to a planar disk electrode and that the entire surface is uniformly electroactive, i.e., the heterogeneous electron transfer reaction can take place at any area. 

Eddowes, M.J. and Hill, H.A.O. (1977) Novel method for the investigation of the electrochemistry of metalloproteins cytochrome c. Journal of the Chemical Society. Chemical Communications,... 

In the early investigations of the direct electrochemistry of metalloproteins, polarography was principally employed. The electrode reaction of cytochrome c at mercury electrodes has been extensively stud-... 

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