Eight-Carbon-Membered Ring Radicals

A spectacular increase in the development and appHcation of radical-based synthetic methodology for ring closures has taken place over the last 20 years or so [1-6]. By far the most popular radical-based strategy rehes on intramolecular addition of a radical (carbon or heteroatom centred) to an unsaturated bond [Scheme 1 (l)j. Cychsations of this type giving three-, four-, eight- and larger-membered rings are considered as unusual [7] and are covered in this review. 

---