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Eigenvalues and positions of equilibrium points

The elimination rate constant A is a time-scale parameter and it does not affect the present stability analysis. [Pg.320]

The forward and reverse rate constants, k+1, and k respectively, govern the affinity. A change in affinity, with the same receptor density, also affects stability. A decrease in affinity (decrease in A or increase in k. expressing the dissociation constant) results in an increase in distance between P. P2, and P3. The parameter n affects exclusively the binding curve. [Pg.320]

The steep negative slope p (y) 0 results in complex eigenvalues. The frequency of the oscillation increases with the steepness. The operating point in such cases is a stable focus. In contrast, shallow negative slopes [Pg.320]




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Eigenvalue

Equilibrium point

Equilibrium position

Point position

Position of equilibrium

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