Effects of Solvent, Leaving Group, and Nucleophile on Unimolecular Substitution

EFFECTS OF SOLVENT, LEAVING GROUP, AND NUCLEOPHILE ON UNIMOLECULAR SUBSTITUTION 

As in Sn2 reactions (Section 6-10), varying the solvent, the leaving group, and the nucleophile greatly affects unimolecular substitution. 

The solvent nitromethane, CH3NO2 (see Table 6-5), is both highly polar and virtually nonnucleophihc. Therefore, it is useful in studies of SnI reactions with nucleophiles other 

The n1 reaction speeds up with better leaving groups 

The strength of the nucleophile affects the product distribution but not the reaction rate 

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