Effects of Pure Antiestrogens

These studies have been focused on the effects of pure antiestrogens on gene expression, on cell growth and proliferation, and on the effects on different growth factors. 

Table 6.2. Effects of pure antiestrogens on experimental animals ...

The effects of pure antiestrogens in the uterus have also been extensively studied, since it is an estrogen-dependent organ and the target of the main side effects of tamoxifen therapy, such as endometrial hyperplasia, hypertrophy of glandular epithelium, or even focal cellular atypia (Sourla et al. 1997). 

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