Effectiveness with FDA

Those involved in drug development must work in concert with FDA. The FDA and industry, working together on a product, will often bring about a development program that is more effective and more efficienf in time and resources. Too many companies fake 

Multiple studies have been done of TCAs in the treatment of nocturnal enuresis, and all consistently show effect over placebo. Most notably, Rapoport et al. (1978) found a significant relationship between IMI plasma level and response to medication. Imipramine is the only medication with FDA approval for treatment of this condition. 

Although studies suggest that antidepressants of any class are efficacious for the treatment of BN, the favorable side effect profile and lower toxicity of the newer generation antidepressants make their use preferable. Of these, fluoxetine is the best studied and is the only antidepressant at this time with FDA approval for the treatment of BN. 

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