Effect in the Elucidation of Reaction Mechanism

Melander has carried out a detailed and thorough investigation of the effect of tritium substitution at the aromatic nucleus on the mechanism of aromatic nitration. He has studied the 

This conclusion is in agreement with that arrived at on the basis of solvent effects on the rate.  

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Recently, oxygen-18 at very high concentrations has become available and the use of oxygen isotope effects in the elucidation of reaction mechanisms may become possible. 

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