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Ecteinascidins cytotoxicity

Some of these cytotoxic marine alkaloids are promising candidates for new drugs. For example, ecteinascidins, Fig. (29) are a family of tetrahydroisoquinolone alkaloids isolated from the Caribbean tunicate Ecteinascidici turbinata, which have been selected for clinical development. These compounds are presently in pre-clinical and clinical trials for human cancers [221-225], A series of totally synthetic molecules that are structurally related to the ecteinascidins is currently being prepared and evaluated as antitumor agents [226],... [Pg.707]

Table 2. In vivo cytotoxicity of Ecteinascidins and Eudistomin K against P-388 leukemia, B-16 melanoma, Lewis Lung carcinoma xenograft (LL), M5076 ovarian sarcoma and MX-1 human mammary carcinoma xenograft, doses in pg/kg/day. ... Table 2. In vivo cytotoxicity of Ecteinascidins and Eudistomin K against P-388 leukemia, B-16 melanoma, Lewis Lung carcinoma xenograft (LL), M5076 ovarian sarcoma and MX-1 human mammary carcinoma xenograft, doses in pg/kg/day. ...
Takahashi, N., Li, W.W., Banerjee, D., Scotto, K.W., and Bertino, J.R. (2001) Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paditaxel in soft tissue sarcoma cells. Clin. Cancer Res., 7, 3251-3257. [Pg.1715]

See other pages where Ecteinascidins cytotoxicity is mentioned: [Pg.75]    [Pg.83]    [Pg.75]    [Pg.218]    [Pg.580]    [Pg.172]    [Pg.25]    [Pg.119]    [Pg.371]    [Pg.40]    [Pg.233]    [Pg.253]    [Pg.255]    [Pg.277]    [Pg.112]    [Pg.112]    [Pg.124]    [Pg.1062]    [Pg.1703]   
See also in sourсe #XX -- [ Pg.255 ]



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Ecteinascidin

Ecteinascidins

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